Interferon-αA human
SIGMA/I4276 - ≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli
Synonym: IFN-αA; Interferon-α2A
CAS Number: 105388-21-4
MDL Number: MFCD01635115
Product Type: Chemical
SDS-PAGE Interferon-αA Human (Cat. No. I4276) was assessed on SDS-PAGE.
| assay | ≥95% |
| biological source | human |
| color | colorless |
| concentration | ≥0.2 mg/mL |
| form | buffered aqueous solution |
| impurities | endotoxin, tested |
| mol wt | 19 kDa |
| packaging | pkg of 20 μg |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01563  |
| Analysis Note: | The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA. |
| Application: | Interferon-αA human has been used to: • study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling • study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication • compare the effect of Monascus pigment derivatives on hepatitis C virus replication |
| Biochem/physiol Actions: | Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. |
| Biochem/physiol Actions: | Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities. |
| Physical form: | Supplied as a solution in 5 mM sodium acetate, pH 4.0. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |