Interferon-αA/D human
SIGMA/I4401 - ≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Synonym: IFN-αA/D
MDL Number: MFCD01635116
Product Type: Chemical
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| assay | ≥95% |
| biological source | human |
| color | colorless |
| form | buffered aqueous solution |
| impurities | endotoxin, tested |
| mol wt | 19 kDa |
| packaging | pkg of 100K units |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01563  |
| Analysis Note: | The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA. |
| Application: | Interferon-αA/D human has been used: • for identification of coronavirus replicase inhibitors • in combination with ACH-806 [1-(4-pentyloxy-3-trifluo • in combination with vitamin D to check reduction in HCV protein production in cell culture |
| Biochem/physiol Actions: | Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. |
| Biochem/physiol Actions: | This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. |
| Physical form: | Solution in phosphate buffered saline containing 0.1% bovine serum albumin |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |