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Fulvestrant

SIGMA/I4409 - >98% (HPLC)

Synonym: (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; Faslodex; ICI 182,780; ZD 182780; ZD 9238; ZM 182780

CAS Number: 129453-61-8
Empirical Formula (Hill Notation): C32H47F5O3S
Molecular Weight: 606.77
MDL Number: MFCD00903953
Linear Formula: C32H47F5O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I4409-25MG 25 mg
 $205.00
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assay >98% (HPLC)
form powder
InChI 1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
InChI key VWUXBMIQPBEWFH-WCCTWKNTSA-N
originator AstraZeneca
Quality Level 100 
SMILES string [H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc24
solubility DMSO: >5 mg/mL
storage temp. 2-8°C
Application: Fulvestrant has been used:
• as an antagonist of estrogen receptor (ERα and ERβ) to reduce hepatocytes proliferation
• as an antagonist of ER for the suppression of estrogen responsive element in human breast cancer MCF-7 cells
• as anti-estrogen in breast cancer cell lines
Biochem/physiol Actions: Fulvestrant (ICI 182,780) is a selective estrogen receptor down-regulator (SERD). Fulvestrant is a high affinity estrogen receptor antagonist. IC50 = 0.29 nM. Fulvestrant is the first "pure" antiestrogen with no agonistic activity both in vitro and in vivo.
Biochem/physiol Actions: Fulvestrant is a 7α-alkylsulphinyl analog of 17β-oestradiol and is structurally different compared to other selective estrogen receptor (ER) modulators (SERMs). It reduces dimerization and nuclear localization of the estrogen receptor (ER). Fulvestrant lowers the level of ER protein in human breast cancer cells. Fulvestrant is preferred for the treatment of women at their menopause having hormone-sensitive advanced breast cancer.
Biochem/physiol Actions: Fulvestrant is a selective estrogen receptor down-regulator (SERD); high affinity estrogen receptor antagonist.
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 25 mg in glass bottle
Hazard statements H413
Precautionary statements P273
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity >98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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