Insulin-like Growth Factor-I Receptor human
SIGMA/I4657 - ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym: IGF-I Receptor
MDL Number: MFCD01323726
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | α-chain ~120 & 150 kDa |
| β subunit ~46 & 50 kDa | |
| packaging | pkg of 50 μg |
| Quality Level | 200  |
| recombinant | expressed in NSO cells |
| storage temp. | −20°C |
| UniProt accession no. | P08069  |
| Analysis Note: | As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa. |
| Analysis Note: | The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay. |
| Application: | Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides. |
| Biochem/physiol Actions: | Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity. |
| Biochem/physiol Actions: | IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity. |
| General description: | IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies. |
| Physical form: | Lyophilized from a 0.2 μm solution in phosphate buffered saline. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |