ICRF-193

SIGMA/I4659 - apoptosis inducer, arabinosidase substrate

Synonym: meso-4,4′-(3,2-Butanediyl)-bis(2,6-piperazinedione)

CAS Number: 21416-88-6
Empirical Formula (Hill Notation): C₁₂H₁₈N₄O₄
Molecular Weight: 282.30
MDL Number: MFCD01702964
Linear Formula: C₁₂H₁₈N₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-I4659-1MG	1 mg	$366.00 1/EA		Add To Favorites
45-I4659-5MG	5 mg	$994.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
biological source	synthetic (organic)
form	powder or flakes
	solid
InChI	1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+
InChI key	OBYGAPWKTPDTAS-OCAPTIKFSA-N
Quality Level	200
SMILES string	C[C@@H]([C@@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
solubility	DMSO: 4 mg/mL
storage temp.	−20°C

Application:	ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.
Biochem/physiol Actions:	ICRF-193 helps in the enhancement of cell cycle without chromosome segregation. It is considered as an important drug for chemo-differentiation therapy against acute promyelocytic leukemia (APL). ICRF-193 serves as an inducer of differentiation between anticancer drugs.
Biochem/physiol Actions:	ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells.^, ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks.
General description:	ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable complex.
Packaging:	1, 5 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H317
Precautionary statements	P280 - P301 + P310 + P330 - P302 + P352
Hazard Codes	Xn
Risk Statements	22-43
Safety Statements	36/37
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352204

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