Ifosfamide

SIGMA/I4909 - ≥98%

Synonym: Ifex; N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide

CAS Number: 3778-73-2
Empirical Formula (Hill Notation): C₇H₁₅Cl₂N₂O₂P
Molecular Weight: 261.09
EC Number: 223-237-3
MDL Number: MFCD00057374
Linear Formula: C₇H₁₅Cl₂N₂O₂P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I4909-1G	1 g	$285.00 1/EA	Add To Favorites
45-I4909-5G	5 g	$1190.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
InChI	1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
InChI key	HOMGKSMUEGBAAB-UHFFFAOYSA-N
Quality Level	200
shipped in	wet ice
SMILES string	ClCCNP1(=O)OCCCN1CCCl
storage temp.	2-8°C

Application:	Ewing sarcoma of the pancreas: a pediatric case report and narrative literature review: This study explores the effectiveness of Ifosfamide in the treatment of rare pediatric Ewing sarcoma of the pancreas, providing valuable insights into the chemotherapeutic management of rare cancers (Liu et al., 2024 ). Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience: Highlights the role of Ifosfamide in osteosarcoma treatment as part of a clinical trial, evaluating its impact on survival rates and treatment outcomes (Bastard et al., 2024 ). Case report: Characteristics and nature of primary cardiac synovial sarcoma: Discusses the utilization of Ifosfamide in managing primary cardiac synovial sarcoma, with an emphasis on its pharmacodynamics and therapeutic efficacy (Kawasaki et al., 2024 ). Dedifferentiated liposarcoma of the spermatic cord: Examines Ifosfamide′s mechanism of action in treating dedifferentiated liposarcoma, contributing to the broader understanding of its application in sarcoma therapy (Panther et al., 2024 ). A Rare Case of Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Associated With Hemophagocytic Lymphohistiocytosis in a Patient With Recurrent Sinusitis: This article details the clinical use of Ifosfamide in treating aggressive lymphoma, underscoring its role in complex cases where standard treatments may not suffice (Christensen et al., 2024 ).
Biochem/physiol Actions:	Ifosfamide is a nitrogen mustard compound that is a structural isomer of cyclophosphamide. Ifosfamide is a prodrug that must be transformed by cytochrome P450 to the biologically active component. It is used as an antineoplastic agent in cancer chemotherapy, but ifosfamide is more likely to cause renal toxicity than cyclophosphamide.
Packaging:	1, 5 g in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H319 - H340 - H350 - H360
Precautionary statements	P201 - P301 + P310 + P330 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	25-36
Safety Statements	26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	41116107

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