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Ibandronate sodium salt

SIGMA/I5784 - ≥97% (NMR), solid

Synonym: (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium; Bondronat

CAS Number: 138844-81-2
Empirical Formula (Hill Notation): C9H22NNaO7P2
Molecular Weight: 341.21
MDL Number: MFCD07197214
Linear Formula: C9H22NNaO7P2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I5784-10MG 10 mg
 $130.00
1/EA		 Add To Favorites
45-I5784-50MG 50 mg
 $508.00
1/EA		 Add To Favorites

 

assay ≥97% (NMR)
color white
form solid
InChI 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
InChI key LXLBEOAZMZAZND-UHFFFAOYSA-M
originator Roche
Quality Level 100 
SMILES string [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
solubility H2O: >10 mg/mL
storage condition protect from light
storage temp. 2-8°C
Application: Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.
Biochem/physiol Actions: Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.
Biochem/physiol Actions: Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Biochem/physiol Actions: Ibandronate sodium is a farnesyl diphosphate synthase inhibitor (IC50 = 20 nM); also a bone resorption inhibitor.
Features and Benefits: This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (NMR)
Storage Temp. 2-8°C
UNSPSC 41106300

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