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Iberiotoxin, recombinant from Mesobuthus tamulus

SIGMA/I5904 - ≥98% (HPLC), recombinant, expressed in E. coli

Synonym: IbTX

Empirical Formula (Hill Notation): C179H276N50O56S7
Molecular Weight: 4248.86
Linear Formula: C179H276N50O56S7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I5904-5UG 5 µg
 $128.00
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45-I5904-10UG 10 µg
 $208.00
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45-I5904-100UG 100 µg
 $612.00
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assay ≥98% (HPLC)
Quality Level 100 
recombinant expressed in E. coli
storage temp. −20°C
Amino Acid Sequence: Glp-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln [Disulfide Bridges: 7−28; 13−33; 17−35]
Application: Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K+ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca2+- activated K+ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.
Biochem/physiol Actions: Exhibits the same activity as the natural form of the toxin
Biochem/physiol Actions: The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 10, 100 μg in glass bottle
Preparation Note: Soluble in aqueous buffers. Stock solutions of 1 μM can be aliquoted and stored at -20 °C for up to 3 months.
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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