Anti-Interleukin-4 Soluble Receptor antibody produced in goat
SIGMA/I6527 - IgG fraction of antiserum, lyophilized powder
Synonym: Anti-IL-4 sR
MDL Number: MFCD02096774
Product Type: Chemical
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| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| neutralization: suitable | |
| western blot: suitable | |
| UniProt accession no. | P24394  |
| Application: | Anti-Interleukin-4 soluble receptor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody is suitable for neutralization reactions at a working concentration of 5-10 μg/ml. This antibody was used for immunostaining of parasympathetic neurons from guinea pig and human neuroblastoma cells at a dilution of 1:200. |
| Biochem/physiol Actions: | The antibody will neutralize human cell surface IL-4 receptor mediated-bioactivity. |
| General description: | Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R. |
| Immunogen: | recombinant human IL-4 soluble receptor (IL-4 sR), expressed in Sf 21 insect cells. |
| Physical form: | Lyophilized from 51.5 μL of a 0.2μm filitered solution in PBS (pH7.4) with 5% trehalose. |
| Preparation Note: | Purified using Protein G. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |