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H-7 dihydrochloride

SIGMA/I7016 - ≥98% (HPLC)

Synonym: 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride; Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

CAS Number: 108930-17-2
Empirical Formula (Hill Notation): C14H17N3O2S · 2HCl
Molecular Weight: 364.29
MDL Number: MFCD00036961
Linear Formula: C14H17N3O2S · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I7016-5MG 5 mg
 $251.00
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45-I7016-25MG 25 mg
 $609.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7016-25MG

 

assay ≥98% (HPLC)
form powder
InChI 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
InChI key OARGPFMFRLLKPF-UHFFFAOYSA-N
Quality Level 200 
SMILES string Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
solubility H2O: 20 mg/mL
storage temp. 2-8°C
Application: H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
Biochem/physiol Actions: Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.
Disclaimer: Light sensitive
General description: H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).
Packaging: 25 mg in poly bottle
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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