3-Isobutyl-1-methylxanthine
SIGMA/I7018 - BioUltra, ≥99%
Synonym: 1-
CAS Number: 28822-58-4
Empirical Formula (Hill Notation): C10H14N4O2
Molecular Weight: 222.24
EC Number: 249-259-3
MDL Number: MFCD00005584
Linear Formula: C10H14N4O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7018-1G
| anion traces | sulfate (SO42-): <0.05% |
| assay | ≥99% |
| cation traces | Al: <0.0005% |
| Ca: <0.005% | |
| Cu: <0.0005% | |
| Fe: <0.005% | |
| K: <0.05% | |
| Mg: <0.005% | |
| Na: <0.005% | |
| NH4+: <0.05% | |
| Pb: <0.001% | |
| Zn: <0.0005% | |
| ign. residue | <0.1% |
| impurities | <0.005% Phosphorus (P) |
| InChI | 1S/C10H14N4O2/c1-6(2)4-14 |
| InChI key | APIXJSLKIYYUKG-UHFFFAOYSA |
| mp | 200-201 °C (lit.) |
| product line | BioUltra |
| Quality Level | 200  |
| SMILES string | CC(C)CN1C(=O)N(C)C(=O)c2[ |
| solubility | DMSO: soluble 1 M (with gentle warming) |
| storage temp. | −20°C |
| Application: | 3-Isobutyl-1-methylxanthi • for adipogenic differentiation • in tissue culture • 3T3-L1 preadipocyte differentiation( |
| Biochem/physiol Actions: | The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons. |
| Biochem/physiol Actions: | The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons. |
| Features and Benefits: | • Trace element testing by ICP • ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content • Ion chromatography testing for trace ammonium content |
| Packaging: | 1 g in poly bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 200-201 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |