Monoclonal Anti-Interleukin-4 antibody produced in mouse
SIGMA/I7034 - clone 3007, purified immunoglobulin, lyophilized powder
Synonym: Anti-IL-4
MDL Number: MFCD00212213
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3007, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG1 |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 5-15.0 μg/mL |
| neutralization: suitable | |
| western blot: 1-2 μg/mL | |
| UniProt accession no. | P05112  |
| Application: | Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml may be used for human tissues and 5-15 μg/ml may be used for human cells. The antibody is suitable for neutralization reactions. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4. |
| Immunogen: | purified, E. coli-derived recombinant human interleukin-4. |
| Physical form: | Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |