IMS2186

SIGMA/I7160 - ≥98% (HPLC), solid

Synonym: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

CAS Number: 1031206-36-6
Empirical Formula (Hill Notation): C₁₈H₁₆O₄
Molecular Weight: 296.32
MDL Number: MFCD12912419
Linear Formula: C₁₈H₁₆O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-I7160-5MG	5 mg	$119.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	solid
InChI	1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
InChI key	BZCADTHMZLYKAR-MDWZMJQESA-N
Quality Level	100
SMILES string	COc1ccc(cc1O)C=C2/COc3ccc(C)cc3C2=O
solubility	DMSO: >20 mg/mL
storage condition	desiccated
storage temp.	room temp

Biochem/physiol Actions:	IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC₅₀= 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
Biochem/physiol Actions:	IMS2186 is an anti-proliferative and anti-angiogenic.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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