Indole-3-carbinol
SIGMA/I7256
Synonym: 3-Indolemethanol
CAS Number: 700-06-1
Empirical Formula (Hill Notation): C9H9NO
Molecular Weight: 147.17
EC Number: 211-836-2
MDL Number: MFCD00005632
Linear Formula: C9H9NO
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7256-25G
| InChI | 1S/C9H9NO/c11-6-7-5-10-9- |
| InChI key | IVYPNXXAYMYVSP-UHFFFAOYSA |
| mp | 96-99 °C (lit.) |
| Quality Level | 100  |
| SMILES string | OCc1c[nH]c2ccccc12 |
| storage temp. | 2-8°C |
| Application: | Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer. |
| Biochem/physiol Actions: | Indole-3-carbinol (I3C) activates aryl hydrocarbon receptor (AhR) and induces G1 cell cycle arrest and apoptosis. Thus, it acts as a potential anti-cancer agent. In addition, it induces estradiol metabolism by stimulating cytochrome P450 enzymes. Therefore, I3C is considered to be a potent chemotherapeutic for various types of cancer including, breast, prostate, colon cancer, and leukemia. |
| Biochem/physiol Actions: | Inhibits cancinogenesis at the initiation stage. Has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage. Found in cruciferous vegetables. |
| General description: | Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts. |
| Packaging: | 1, 5, 25 g in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 96-99 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352005 |