Indomethacin
SIGMA/I7378 - 98.5-100.5% (in accordance with EP)
Synonym: 1-
CAS Number: 53-86-1
Empirical Formula (Hill Notation): C19H16ClNO4
Molecular Weight: 357.79
EC Number: 200-186-5
MDL Number: MFCD00057095
Linear Formula: C19H16ClNO4
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7378-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7378-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7378-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7378-5G
| assay | 98.5-100.5% (in accordance with EP) |
| biological source | synthetic |
| form | powder or crystals |
| InChI | 1S/C19H16ClNO4/c1-11-15(1 |
| InChI key | CGIGDMFJXJATDK-UHFFFAOYSA |
| loss | ≤0.5% loss on drying |
| mode of action | enzyme | inhibits |
| mp | 158-162 °C |
| Quality Level | 200  |
| SMILES string | COc1ccc2n(c(C)c(CC(O)=O)c |
| Application: | Indomethacin has been used: • as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells • as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture • in the inhibition of prostaglandin E2 (PGE2) in T cells |
| Biochem/physiol Actions: | Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis. |
| Packaging: | 10, 25, 100 g in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN 2811 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 98.5-100.5% (in accordance with EP); 98.5-100.5% (in accordance with EP) |
| mp | 158-162 °C |
| UNSPSC | 12161501 |