Imipramine hydrochloride
SIGMA/I7379 - ≥99% (TLC)
Synonym: 10,11-
CAS Number: 113-52-0
Empirical Formula (Hill Notation): C19H24N2 · HCl
Molecular Weight: 316.87
EC Number: 204-030-7
MDL Number: MFCD00012669
Linear Formula: C19H24N2 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7379-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I7379-5G
| assay | ≥99% (TLC) |
| color | white |
| form | powder |
| InChI | 1S/C19H24N2.ClH/c1-20(2)1 |
| InChI key | XZZXIYZZBJDEEP-UHFFFAOYSA |
| originator | Novartis |
| Quality Level | 200  |
| SMILES string | Cl[H].CN(C)CCCN1c2ccccc2C |
| solubility | H2O: 50 mg/mL |
| Application: | Imipramine hydrochloride has been used: • as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals • to investigate its interaction with insulin in aqueous solution • to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification |
| Biochem/physiol Actions: | Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM). |
| Biochem/physiol Actions: | Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter. |
| Features and Benefits: | This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring. |
| Packaging: | 5, 25, 100 g in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (TLC) |
| UNSPSC | 12352116 |