Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse
SIGMA/I7409 - clone 409405, purified immunoglobulin, lyophilized powder
Synonym: Anti-IL1; Anti-IL1A
MDL Number: MFCD00162513
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 409405, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG2b |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1-2 μg/mL |
| UniProt accession no. | P01583  |
| Application: | Anti-interleukin 1α antibody is suitable for immunoblotting at a working concentration of 1-2 μg/ml. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. The IL-1α precursor produced initially is cleaved by calpain to produce a 16 kDa propeptide and 17 kDa mature protein. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The propeptide has nuclear localization sequence that enables it to shuttle to nucleus and activate transcription of target genes. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation.Overproducti Monoclonal Anti-Interleukin-1a propeptide recognizes human Interleukin-1α propeptide. It does not cross-react with mature forms of mouse IL-1α or rabbit IL-1α. |
| Immunogen: | purified, E. coli-derived recombinant human interleukin-1α propeptide (aa 1-112). |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |