Interleukin-2 human
SIGMA/I7908 - recombinant, expressed in Pichia pastoris, suitable for cell culture
Synonym: IL-2; Interleukin-2; T-cell growth factor
MDL Number: MFCD00165721
Product Type: Chemical
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| assay | ≥98% (SDS-PAGE and HPLC) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | predicted mol wt ~15 kDa |
| packaging | pkg of 10KU |
| Quality Level | 200  |
| recombinant | expressed in Pichia pastoris |
| shipped in | dry ice |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P60568  |
| Analysis Note: | The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2. |
| Application: | Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs. |
| Biochem/physiol Actions: | Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity. |
| Biochem/physiol Actions: | Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE and HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |