Anti-Interleukin-8 antibody produced in goat
SIGMA/I8026 - affinity isolated antibody, lyophilized powder
Synonym: Anti-CXCL8; Anti-IL-8
MDL Number: MFCD00212220
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunocytochemistry: 5-15 μg/mL |
| immunohistochemistry: 5-15 μg/mL | |
| neutralization: suitable | |
| western blot: 0.1 μg/mL |
| Application: | Anti-Interleukin-8 antibody can be used for the following : • For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8. • Immunoblotting. • ELISA. |
| Application: | Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry. |
| Biochem/physiol Actions: | Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis. |
| Biochem/physiol Actions: | The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3. |
| Immunogen: | recombinant human IL-8 (CXCL8). |
| Physical form: | Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |