3-Iodo-L-tyrosine
SIGMA/I8250
Synonym: 3-Monoiodo-L-tyrosine
CAS Number: 70-78-0
Empirical Formula (Hill Notation): C9H10INO3
Molecular Weight: 307.09
EC Number: 200-744-8
MDL Number: MFCD00002608
Linear Formula: IC6H3-4-(OH)CH2CH(NH2)CO2H
Product Type: Chemical
| impurities | ~5% tyrosine |
| InChI | 1S/C9H10INO3/c10-6-3-5(1- |
| InChI key | UQTZMGFTRHFAAM-ZETCQYMHSA |
| mp | 210 °C (dec.) (lit.) |
| Quality Level | 200  |
| SMILES string | N[C@@H](Cc1ccc(O)c(I)c1)C |
| solubility | dilute aqueous acid: soluble |
| storage temp. | −20°C |
| Application: | 3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae. |
| Biochem/physiol Actions: | 3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter. |
| Biochem/physiol Actions: | TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset. |
| Biochem/physiol Actions: | Tyrosine hydroxylase inhibitor. |
| General description: | Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3). |
| Packaging: | 1, 5, 25 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 210 °C (dec.) (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |