Ivermectin

SIGMA/I8898

Synonym: 22,23-Dihydroavermectin B1; MK-933

CAS Number: 70288-86-7
MDL Number: MFCD00869511
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I8898-250MG	250 mg	$41.00 1/EA	Add To Favorites
45-I8898-1G	1 g	$121.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: I8898-1G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	parasites
application(s)	agriculture environmental
form	powder
InChI	1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChI key	AZSNMRSAGSSBNP-XPNPUAGNSA-N
mode of action	cell membrane \| interferes
originator	Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level	100
SMILES string	[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](CC=C(C)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)C=CC=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
solubility	MEK: 50 mg/mL
storage temp.	2-8°C

Application:	Ivermectin has been used: • in Caenorhabditis elegans fecundity assay • in larval development test • to measure in vivo topical acaricide activity of compounds in rats • to assess its acute and chronic effects to zebrafish • in percutaneous drug injection method to treat cystic echinococcosis • in liquid chromatography with fluorescence detection method
Biochem/physiol Actions:	Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
Features and Benefits:	This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.
Other Notes:	Primarily ivermectin B_1a.
Packaging:	1 g in poly bottle
Packaging:	250 mg in poly bottle

Symbol	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H300 - H311 - H351 - H360D - H410
Precautionary statements	P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312
Hazard Codes	T+
Risk Statements	61-28
Safety Statements	53-28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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