Insulin-like Growth Factor-II from mouse
SIGMA/I8904 - IGF-II, recombinant, expressed in E. coli, lyophilized powder
Synonym: IGF-II
MDL Number: MFCD00241895
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | >97% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized powder |
| impurities | <1.0EUper1mg (LAL test) |
| mol wt | ~7.4 kDa |
| packaging | pkg of 50 μg |
| pkg of 5X50 μg | |
| quality | endotoxin tested |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| UniProt accession no. | P09535  |
| Analysis Note: | The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7. |
| Biochem/physiol Actions: | Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney. |
| General description: | Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions. |
| Packaging: | 50 μg in poly bottle |
| Physical form: | Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |