Anti-Interleukin-1α antibody produced in goat
SIGMA/I8909 - IgG fraction of antiserum, lyophilized powder
Synonym: Anti-IL-1α
MDL Number: MFCD00165461
Product Type: Chemical
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| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | neutralization: suitable |
| western blot: 1-2 μg/mL | |
| UniProt accession no. | P01583  |
| Application: | Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for neutralization reactions. |
| General description: | Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α in neutralization reactions. It shows 5% cross reactivity with mouse IL-1α in immunoblotting applications. |
| Immunogen: | purified, E. coli-derived recombinant human interleukin-1α. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |