Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse
SIGMA/I9031 - ~1 mg/mL, clone 186-2G9, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-ICAM-3
MDL Number: MFCD01094485
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 186-2G9, monoclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 120 kDa |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | direct immunofluorescence: 2 μg using 1 mg protein lysate |
| flow cytometry: 2 μg using 1 mg protein lysate | |
| immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections | |
| immunoprecipitation (IP): 2 μg using 1 mg protein lysate | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P32942  |
| Biochem/physiol Actions: | The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion. |
| General description: | The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2. |
| Immunogen: | stimulated human leukocytes. |
| Physical form: | Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |