Interleukin-10/Fc Chimera (non-lytic) human
SIGMA/I9404 - >98% (SDS-PAGE), recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonym: IL-10:Fc (non-lytic) human
MDL Number: MFCD03457245
Product Type: Chemical
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| assay | >98% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous solution |
| impurities | endotoxin, tested |
| mol wt | 98 kDa |
| packaging | pkg of 10 μg |
| Quality Level | 200  |
| recombinant | expressed in NS.1 cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P22301  |
| Biochem/physiol Actions: | IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells. |
| Biochem/physiol Actions: | Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain. |
| General description: | The gene IL-10 (interleukin-10) is mapped to human chromosome 1q31-32. It is secreted by monocytes and lymphocytes. |
| Other Notes: | Dimeric fusion protein consisting of human IL-10 fused to mutant human IgG1 Fc. |
| Physical form: | Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |