Ionomycin from Streptomyces conglobatus

SIGMA/I9657 - ≥98% (HPLC)

CAS Number: 56092-81-0
Empirical Formula (Hill Notation): C₄₁H₇₂O₉
Molecular Weight: 709.00
MDL Number: MFCD06798385
Linear Formula: C₄₁H₇₂O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-I9657-1MG	1 mg	$216.00 1/EA	Add To Favorites
45-I9657-5MG	5 mg	$865.00 1/EA	Add To Favorites

Calcium Ionomycin is a polyether antibiotic produced by Streptomyces conglobatus (ATCC 31005). Calcium Ionomycin is capable of extracting Ca2+ and other divalent cations from an aqueous into an organic phase. Calcium salt of ionomycin is an effective mobile Ca + carrier and it has significant advantages for use in studies of Ca2+ transport across biological membranes. Calcium Ionomycin can serve as an inducer of apoptosis, which was suggested to act by activation of a latent, calcium-responsive endonuclease.

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
assay	≥98% (HPLC)
biological source	Streptomyces conglobatus
InChI	1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key	PGHMRUGBZOYCAA-ADZNBVRBSA-N
mode of action	cell membrane \| interferes
Quality Level	300
SMILES string	C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)C=C(/O)[C@H](C)C[C@H](C)CC=C[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
solubility	acetonitrile: 10 mg/mL
storage temp.	−20°C

Application:	Ionomycin from Streptomyces conglobatus has been used: • in magnesium-ionomycin treatment experiments • as a supplement in calcium-free Dulbecco′s modified Eagle medium (DMEM) for ionophore treatment • in the restimulation of peripheral blood mononuclear cells (PBMCs) to analyze cytokine production using flow cytometry (FCM) • as a calcium ionophore to treat oocytes to perform intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)
Biochem/physiol Actions:	Ionomycin is a polyether antibiotic and an ionophore produced by the bacterium Streptomyces conglobatus. This Ca²⁺ ionophore is more effective than A23187 as a mobile ion carrier for Ca²⁺. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons. Ionomycin has been shown to induce central demyelination, inhibit adrenal bovine TREK-1 channels, and regulate cell division of mature human B cells. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress, and intrinsic apoptosis mechanisms. It also stimulates the intracellular production of cytokines, interferon, perforin, interleukin-2 (IL-2), and IL-4 usually in conjunction with PMA.
Biochem/physiol Actions:	Ionomycin is highly specific for divalent cations. It may have antiproliferative effects on the human bladder cancer cell line both in vitro and in vivo. Ionomycin functions as an apoptosis inducer which was suggested to act by activation of a latent, calcium-responsive endonuclease.
Packaging:	1, 5 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51102829

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