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Imidazolo-oxindole PKR inhibitor C16

SIGMA/I9785 - ≥98% (HPLC)

Synonym: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

CAS Number: 608512-97-6
Empirical Formula (Hill Notation): C13H8N4OS
Molecular Weight: 268.29
MDL Number: MFCD06735404
Linear Formula: C13H8N4OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I9785-5MG 5 mg
 $117.00
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45-I9785-25MG 25 mg
 $462.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow to orange-brown
InChI 1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChI key VFBGXTUGODTSPK-BAQGIRSFSA-N
Quality Level 100 
shipped in wet ice
SMILES string O=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4
solubility DMSO: 12 mg/mL
storage temp. −20°C
Application: Imidazolo-oxindole PKR inhibitor C16 has been used:
• to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
• to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
• to augment eukaryotic translation initiation factor 2 (eIF2) activity
Biochem/physiol Actions: C16 exhibits a neuroprotective role in adult brain injuries.
Biochem/physiol Actions: Imidazolo-oxindole PKR inhibitor C16 is a selectiv inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2).
Biochem/physiol Actions: Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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