Interleukin-2/Fc Chimera (non-lytic) from mouse
SIGMA/I9905 - >98% (SDS-PAGE), recombinant, expressed in CHO cells, solution
Synonym: IL-2:Fc (non-lytic)
MDL Number: MFCD03457247
Product Type: Chemical
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| assay | >98% (SDS-PAGE) |
| biological source | mouse |
| concentration | 0.1 mg/mL |
| form | solution |
| impurities | endotoxin, tested |
| mol wt | 94 kDa |
| packaging | pkg of 10 μg |
| Quality Level | 200  |
| recombinant | expressed in CHO cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P04351  |
| Analysis Note: | The biological activity is measured in a cell proliferation assay using CTLL2 cells. |
| Biochem/physiol Actions: | IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D). |
| Biochem/physiol Actions: | Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain. |
| Other Notes: | Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc. |
| Physical form: | Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4. |
| Purity | >98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |