JNK1, active, GST tagged from mouse
SIGMA/J2455 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: JNK; JNK1A1; JNK21B1/2; PRKM8; SAPK1
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~71 kDa |
| product line | PRECISIO® Kinase |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 92-124 nmol/min·mg |
| storage temp. | −70°C |
| UniProt accession no. | Q91Y86  |
| Biochem/physiol Actions: | As a member of the MAP kinase family, JNK1 is known to play a role in the induction of apoptosis through various stimuli such as TNFa.JNK1 also is influences cell migration via phosphorylation of paxillin.JNK1 is also a crucial mediator of obesity and insulin resistance and a potential target for therapeutics. |
| Biochem/physiol Actions: | JNK1 (c-Jun N-terminal kinase 1) is a member of the MAPK (mitogen activated protein kinase) family that controls gene expression by phosphorylation of transcription factors. It is linked with apoptosis, brain development and learning ability. JNK1 also influences cell migration via phosphorylation of paxillin. JNK1 also regulates obesity and insulin resistance. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| activity | specific activity: 92-124 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |