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JNJ 17203212

SIGMA/J3580 - ≥98% (HPLC)

Synonym: N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine

CAS Number: 821768-06-3
Empirical Formula (Hill Notation): C17H15F6N5O
Molecular Weight: 419.32
Linear Formula: C17H15F6N5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-J3580-5MG 5 mg
 DISCONTINUED  
45-J3580-25MG 25 mg
 DISCONTINUED  

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChI key JFRYYGVYCWYIDQ-UHFFFAOYSA-N
originator Johnson & Johnson
SMILES string FC(F)(F)c1c(nccc1)N2CCN(CC2)C(=O)Nc3ncc(cc3)C(F)(F)F
solubility DMSO: >20 mg/mL
storage temp. −20°C
Biochem/physiol Actions: JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.
Biochem/physiol Actions: JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist.
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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