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JNJ7777120

SIGMA/J3770 - ≥98% (HPLC)

Synonym: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine

CAS Number: 459168-41-3
Empirical Formula (Hill Notation): C14H16N3OCl
Molecular Weight: 277.75
MDL Number: MFCD04343337
Linear Formula: C14H16N3OCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-J3770-5MG 5 mg
 $181.00
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45-J3770-25MG 25 mg
 $679.00
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assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChI key HUQJRYMLJBBEDO-UHFFFAOYSA-N
originator Johnson & Johnson
Quality Level 100 
SMILES string CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
solubility DMSO: >20 mg/mL
  H2O: insoluble
storage temp. room temp
Application: JNJ7777120 has been used as a histamine-4 receptor antagonist:
• to study its effects on the pro-inflammatory microglia in rats
• to study its effects on the Parkinson′s-like pathology in rat brain
• to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
Biochem/physiol Actions: JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
Biochem/physiol Actions: JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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