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JTE-013

SIGMA/J4080 - ≥98% (HPLC)

Synonym: 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide

CAS Number: 383150-41-2
Empirical Formula (Hill Notation): C17H19N7OCl2
Molecular Weight: 408.29
Linear Formula: C17H19N7OCl2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-J4080-5MG 5 mg
 $170.00
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45-J4080-25MG 25 mg
 $676.00
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
InChI key RNSLRQNDXRSASX-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1nc(cc(c1)NC(=O)NNc2nc3[n](nc(c3c(c2)C(C)C)C)C)Cl
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: JTE-013 has been used in in vitro blood−brain barrier (BBB) and blood−tumor barrier (BTB) assays.
Biochem/physiol Actions: JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.
Biochem/physiol Actions: JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist.
Biochem/physiol Actions: JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist. JTE-013 is highly selective for S1P2 (EDG-5). It inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 mM, JTE-013 displays 4.2% inhibition of S1P3 and does not antagonise S1P1.
Features and Benefits: This compound is featured on the Lysophospholipid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352211

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