Jo-1 human
SIGMA/J4144 - recombinant, expressed in E. coli, solution
MDL Number: MFCD03457272
Product Type: Chemical
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| form | solution |
| mol wt | 55 kDa by SDS-PAGE |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P12081  |
| Biochem/physiol Actions: | The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyosi |
| Biochem/physiol Actions: | Used in the immunoassay for antibodies to Jo-1. |
| General description: | Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity. |
| Physical form: | Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |