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Jervine

SIGMA/J4145 - ≥98% (HPLC), powder

Synonym: (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one; 11-Ketocyclopamine

CAS Number: 469-59-0
Empirical Formula (Hill Notation): C27H39NO3
Molecular Weight: 425.60
EC Number: 207-417-9
MDL Number: MFCD01684066
Linear Formula: C27H39NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-J4145-1MG 1 mg
 $173.00
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assay ≥98% (HPLC)
form powder
InChI 1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
InChI key CLEXYFLHGFJONT-DNMILWOZSA-N
Quality Level 100 
SMILES string [H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2
solubility H2O: insoluble
  methanol: >2 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Jervine is a potent teratogenic agent. It can induce apoptosis in leukemia cells and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment. Jervine may be used for treating hypertension and heart disease.
Biochem/physiol Actions: Jervine is a sonic hedgehog (Shh) pathway inhibitor.
General description: Jervine is a steroid alkaloid present in Veratrum californicum.
Packaging: 1 mg in glass bottle
Symbol GHS06GHS08  GHS06,GHS08
Signal word Danger
Hazard statements H301 - H360D
Precautionary statements P201 - P301 + P310 + P330
Hazard Codes Xn
Risk Statements 22
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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