JSH-23

SIGMA/J4455 - ≥98% (HPLC), solid

Synonym: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

CAS Number: 749886-87-1
Empirical Formula (Hill Notation): C₁₆H₂₀N₂
Molecular Weight: 240.34
Linear Formula: C₁₆H₂₀N₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-J4455-5MG	5 mg	$181.00 1/EA		Add To Favorites
45-J4455-25MG	25 mg	$720.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to gray-pink
form	solid
InChI	1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key	YMFNPBSZFWXMAD-UHFFFAOYSA-N
Quality Level	100
shipped in	wet ice
SMILES string	N(CCCc2ccccc2)c1c(cc(cc1)C)N
solubility	DMSO: >10 mg/mL
storage condition	protect from light
storage temp.	−20°C

Application:	JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Biochem/physiol Actions:	JSH-23 is an inhibitor of NF-kB nuclear translocation.
Biochem/physiol Actions:	JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
Other Notes:	Light and air sensitive.
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn,N
Risk Statements	22-41-50/53
Safety Statements	26-39-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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