Jasplakinolide

SIGMA/J4580 - ≥97% (HPLC)

Synonym: Jaspamide

CAS Number: 102396-24-7
Empirical Formula (Hill Notation): C₃₆H₄₅BrN₄O₆
Molecular Weight: 709.67
MDL Number: MFCD00873735
Linear Formula: C₃₆H₄₅BrN₄O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-J4580-100UG	100 µg	$815.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	off-white to beige
form	film (colorless)
InChI	1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
InChI key	GQWYWHOHRVVHAP-DHKPLNAMSA-N
Quality Level	100
shipped in	wet ice
SMILES string	C[C@H]1C[C@@H](C)C=C(C)C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4
solubility	DMSO: >2 mg/mL
storage temp.	−20°C

Application:	Jasplakinolide has been used to analyze its influence on sciatic nerve guidance effect in vivo in chicken embryos. It has also been used to apply on the control cells for the treatment for blocking actin dynamics.
Biochem/physiol Actions:	Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments.
Biochem/physiol Actions:	Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.
Packaging:	100 μg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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