Synonym: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine; RWJ 540973
CAS Number: 627518-40-5
Empirical Formula (Hill Notation): C18H16FN3O2
Molecular Weight: 325.34
Linear Formula: C18H16FN3O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
off-white |
| form |
solid |
| InChI |
1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) |
| InChI key |
ZDNURMVOKAERHZ-UHFFFAOYSA-N |
| originator |
Johnson & Johnson |
| Quality Level |
100  |
| SMILES string |
COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC |
| solubility |
DMSO: >10 mg/mL |
| |
H2O: <2 mg/mL |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase. |
| Biochem/physiol Actions: |
JNJ-10198409 is an ATP-competitive Platelet-Derived Growth Factor Receptor-beta (PDGFR-β) inhibitor. |
| Features and Benefits: |
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound is featured on the PAF Receptor and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: |
This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: |
1, 5 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
51111800 |
