Kaempferol
SIGMA/K0133 - ≥90% (HPLC), powder
Synonym: 3,4′,5,7-Tetrahydroxyflavone; 3,5,7-
CAS Number: 520-18-3
Empirical Formula (Hill Notation): C15H10O6
Molecular Weight: 286.24
MDL Number: MFCD00016938
Linear Formula: C15H10O6
Product Type: Chemical
| assay | ≥90% (HPLC) |
| biological source | synthetic |
| color | yellow |
| form | powder |
| InChI | 1S/C15H10O6/c16-8-3-1-7(2 |
| InChI key | IYRMWMYZSQPJKC-UHFFFAOYSA |
| mp | 277 °C |
| Quality Level | 100  |
| SMILES string | Oc1ccc(cc1)C2=C(O)C(=O)c3 |
| solubility | DMSO: 50 mg/mL |
| ethanol: 20 mg/mL | |
| storage condition | protect from light |
| storage temp. | room temp |
| Application: | Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range. |
| Application: | Kaempferol (KAE) has been used: • to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5 cells • to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs) • to study its apoptosis sensitizing effect on non-small cell lung cancer (NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2) |
| Biochem/physiol Actions: | Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol. |
| Biochem/physiol Actions: | The diphenylpropane component of Kaempferol contributes to its hydrophobic properties. It has shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent with lipid peroxidation. It also inhibits topoisomerase I catalyzed DNA religation. Kaempferol may also inhibit the activity of fatty acid synthase. |
| General description: | Kaempferol is a natural dietary flavonoid and a polyphenol antioxidant found in various fruits and vegetables. Kaempferol is present in plants in a different glycosidic form such as astragalin by binding with different sugars. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | T |
| Risk Statements | 25-68 |
| Safety Statements | 36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| mp | 277 °C |
| Storage Temp. | room temp |
| UNSPSC | 12191503 |