Kainic acid monohydrate

SIGMA/K0250 - ≥99% (TLC)

Synonym: Digenin, Kainate; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

CAS Number: 58002-62-3
Empirical Formula (Hill Notation): C₁₀H₁₅NO₄ · H₂O
Molecular Weight: 231.25
MDL Number: MFCD00150833
Linear Formula: C₁₀H₁₅NO₄ · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K0250-10MG	10 mg	$268.00 1/EA	Add To Favorites
45-K0250-50MG	50 mg	$1180.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (TLC)
form	powder
impurities	Glutamate, free
InChI	1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
InChI key	FZNZRJRSYLQHLT-SLGZUKMRSA-N
Quality Level	100
SMILES string	O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
solubility	H₂O: soluble
storage temp.	2-8°C

Application:	Kainic acid (KA) has been used: • tostudy mechanisms of excitation-induced apoptosis and epilepsy. • to hamper themitochondrial function () • used to induce c-fosexpression in the mice′s brains, specifically targeting the dorsal hippocampus.()
Biochem/physiol Actions:	Agonist for kainate class of ionotropic glutamate receptors.
Biochem/physiol Actions:	Kainic acid monohydrate disrupts mitochondrial function by inducing the release of lactate dehydrogenase (LDH) and reducing 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). It also triggers the generation of lipid peroxides, which are key mediators in initiating and regulating inflammation and oxidative stress.
Biochem/physiol Actions:	Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Excitatory Amino Acid Transporters and Glutamate Receptors (Ion Channel Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Kainic acid monohydrate serves as an agonist for kainate-class ionotropic glutamate receptors, initiating seizures and neurodegeneration in live organisms. It is employed to induce experimental epilepsy in rodents and to explore the mechanisms underlying excitation-induced neuronal apoptosis.
Packaging:	10, 50 mg in glass insert
Preparation Note:	Dissolve in 1-2 drops of 1N NaOH then bring to volume with water or aqueous buffer. Can be stored 1-2 days refrigerated.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352106

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