Kanamycin solution from Streptomyces kanamyceticus

SIGMA/K0254 - 50 - 60 mg/mL in 0.9% NaCl, BioReagent, liquid, 0.1 μm filtered, suitable for cell culture

Synonym: Kanamycin A

CAS Number: 25389-94-0
MDL Number: MFCD00070289
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-K0254-20ML	20 mL	$77.90 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
biological source	Streptomyces kanamyceticus
concentration	50 - 60 mg/mL in 0.9% NaCl
form	liquid
impurities	endotoxin, tested
InChI	1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1
InChI key	SBUJHOSQTJFQJX-NOAMYHISSA-N
mode of action	protein synthesis \| interferes
product line	BioReagent
Quality Level	200
SMILES string	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
sterility	0.1 μm filtered
storage temp.	2-8°C
technique(s)	cell culture \| mammalian: suitable
	cell culture \| plant: suitable

Application:	Kanamycin solution from Streptomyces kanamyceticus has been used: • to induce deafness in neonatal rats • as an endothelial growth medium component for culturing human umbilical vein endothelial cells (HUVECs) • as medium component for Mycobacteria Cultures and Top10 E coli cells
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Disclaimer:	Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
General description:	Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352207

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