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Sodium 4-methyl-2-oxovalerate

SIGMA/K0629 - leucine metabolite

Synonym: α-Ketoisocaproic acid sodium salt; 4-Methyl-2-oxopentanoic acid sodium salt; 4-Methyl-2-oxovaleric acid sodium salt; Ketoleucine sodium salt

CAS Number: 4502-00-5
Empirical Formula (Hill Notation): C6H9NaO3
Molecular Weight: 152.12
EC Number: 224-816-3
MDL Number: MFCD00064193
Linear Formula: (CH3)2CHCH2COCOONa
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K0629-1G 1 g
 $0.00
1/EA
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45-K0629-5G 5 g
 $422.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: K0629-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: K0629-5G

 

application(s) cell analysis
assay >98% (TLC)
color white to off-white
form powder
InChI 1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1
InChI key IXFAZKRLPPMQEO-UHFFFAOYSA-M
mp 275 °C (dec.) (lit.)
Quality Level 100 
SMILES string [Na+].CC(C)CC(=O)C([O-])=O
storage temp. 2-8°C
technique(s) HPLC: suitable
Application: Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method.
Biochem/physiol Actions: α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria.
Packaging: 1, 5 g in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (TLC)
mp 275 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 12352107

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