KT 5823

SIGMA/K1388 - ≥85% (HPLC), lyophilized powder

CAS Number: 126643-37-6
Empirical Formula (Hill Notation): C₂₉H₂₅N₃O₅
Molecular Weight: 495.53
MDL Number: MFCD09878278
Linear Formula: C₂₉H₂₅N₃O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-K1388-100UG	100 µg	$241.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
color	white
form	lyophilized powder
InChI	1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChI key	QTYMDECKVKSGSM-YMUMJAELSA-N
Quality Level	100
SMILES string	COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC
solubility	ethyl acetate: 5 mg/mL
storage temp.	2-8°C

Application:	KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.
Biochem/physiol Actions:	Selective inhibitor of PKG.
Features and Benefits:	This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na⁺/I⁻ symporter (NIS) expression.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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