Kininogen high molecular weight, Two Chain from human plasma
SIGMA/K1632 - lyophilized powder
MDL Number: MFCD00131428
Product Type: Chemical
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| biological source | human plasma |
| form | lyophilized powder |
| Quality Level | 200  |
| solubility | H2O: soluble 0.1 mg protein/mL |
| storage temp. | −20°C |
| UniProt accession no. | P01042  |
| Biochem/physiol Actions: | High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis. |
| Biochem/physiol Actions: | High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets. |
| General description: | High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex. |
| General description: | HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein. |
| Packaging: | Package size based on protein content |
| Physical form: | Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl |
| Preparation Note: | Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |