Kanamycin disulfate salt from Streptomyces kanamyceticus

SIGMA/K1876 - aminoglycoside antibiotic

Synonym: Kanamycin Disulfate Salt; Kanamycin disulfate; O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-Streptamine sulfate (1:2) (salt); Kanamycin A; Kanamycin acid sulfate

CAS Number: 64013-70-3
MDL Number: MFCD00143916
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K1876-1G	1 g	$28.90 1/EA	Add To Favorites
45-K1876-5G	5 g	$76.20 1/EA	Add To Favorites
45-K1876-25G	25 g	$339.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
biological source	Streptomyces kanamyceticus
color	white to off-white
form	powder
impurities	≤4% Kanamycin B
InChI	1S/C18H36N4O11.2H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;21-5(2,3)4/h4-18,23-29H,1-3,19-22H2;2(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;;/m1../s1
InChI key	OGTKIXVMLDAMNU-KNQICTBBSA-N
mode of action	protein synthesis \| interferes
potency	~650 μg per mg
Quality Level	200
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
solubility	H₂O: 10 mg/mL

Application:	Kanamycin sulfate is a broad spectrum minoglycoside-antibiotic It is used as an additive in culture media for the isolation of group D Streptococci on Kanamycin Esculin Azide Agar (Mossel et al.) or for selection of transformed plant cells containing the neomycin phosphotransferase (for kanamycin resistance); on a kanamycin-medium. Kanamycin has been used for electrophysiological recordings of outer hair cells and inner hair cells. It is used to inhibit shoot regeneration from Siberian Elmleaf explants. It is recommended for use in cell culture applications at 100 mg/mL.
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Disclaimer:	Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
General description:	Chemical structure: aminoglycoside
Preparation Note:	Kanamycin acid sulfate is prepared by solubilizing kanamycin sulfate in dilute sulfuric acid and drying. The sulfate content is approximately 25%.
Preparation Note:	Kanamycin sulfate is soluble in water at 10 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51281654

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