K-252a
SIGMA/K2015 - Ready Made Solution, from Nonomuraea longicatena, >98%
Synonym: SF 2370
CAS Number: 99533-80-9
Empirical Formula (Hill Notation): C27H21N3O5
Molecular Weight: 467.47
EC Number: 200-664-3
MDL Number: MFCD00161522
Linear Formula: C27H21N3O5
Product Type: Chemical
| assay | >98% |
| biological source | Nonomuraea longicatena |
| form | solution |
| InChI | 1S/C27H21N3O5/c1-26-27(33 |
| InChI key | KOZFSFOOLUUIGY-SOLYNIJKSA |
| Quality Level | 200  |
| shipped in | dry ice |
| SMILES string | [H][C@]12C[C@](O)(C(=O)OC |
| storage temp. | −20°C |
| Biochem/physiol Actions: | K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis. |
| Features and Benefits: | This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Physical form: | Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO). |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| Purity | >98% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |