Synonym: (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
CAS Number: 108068-98-0
Empirical Formula (Hill Notation): C32H31N3O5
Molecular Weight: 537.61
MDL Number: MFCD00132118
Linear Formula: C32H31N3O5
Product Type: Chemical
| assay |
≥98% (HPLC) |
| biological source |
microbial |
| color |
white to faint yellow |
| form |
powder |
| InChI |
1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1 |
| InChI key |
ZHEHVZXPFVXKEY-IKZDWWSZSA-N |
| Quality Level |
200  |
| shipped in |
wet ice |
| SMILES string |
CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O |
| solubility |
methanol: 5 mg/mL |
| storage temp. |
−20°C |
| Application: |
KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression. |
| Biochem/physiol Actions: |
Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK). |
| Features and Benefits: |
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
51111800 |
