Kenpaullone

SIGMA/K3888 - ≥98%

Synonym: 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; NSC 664704

CAS Number: 142273-20-9
Empirical Formula (Hill Notation): C₁₆H₁₁BrN₂O
Molecular Weight: 327.18
MDL Number: MFCD02683595
Linear Formula: C₁₆H₁₁BrN₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-K3888-1MG	1 mg	$167.00 1/EA		Add To Favorites
45-K3888-5MG	5 mg	$599.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
color	yellow
form	solid
InChI	1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChI key	QQUXFYAWXPMDOE-UHFFFAOYSA-N
Quality Level	100
SMILES string	Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
solubility	DMSO: 18 mg/mL, clear, yellow
storage temp.	2-8°C

Application:	Kenpaullone has been used: • as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines • as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice • as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development
Biochem/physiol Actions:	Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.
Features and Benefits:	This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	1, 5 mg in glass bottle
Packaging:	Store under argon

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	12352200

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