Synonym: 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol
CAS Number: 19408-46-9
Empirical Formula (Hill Notation): C14H25N3O9 · HCl
Molecular Weight: 415.82
MDL Number: MFCD00058459
Linear Formula: C14H25N3O9 · HCl
Product Type: Chemical
| antibiotic activity spectrum |
Gram-negative bacteria |
| |
Gram-positive bacteria |
| biological source |
Streptomyces kasugaensis |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1 |
| InChI key |
ZDRBJJNXJOSCLR-NZXABURVSA-N |
| mode of action |
protein synthesis | interferes |
| Quality Level |
200  |
| SMILES string |
C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl |
| storage temp. |
2-8°C |
| Application: |
Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance. |
| Biochem/physiol Actions: |
Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit. |
| General description: |
Chemical structure: aminoglycoside |
| Packaging: |
10 g in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
2-8°C |
| UNSPSC |
51102829 |
