PKCη, active, GST tagged human
SIGMA/K4143 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: MG C26269; MG C5363; PKCL; PRK CL; PRKCH; nPKC-eta
Product Type: Chemical
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| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~73 kDa |
| product line | PRECISIO® Kinase |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 73-99 nmol/min·mg |
| storage temp. | −70°C |
| UniProt accession no. | P24723  |
| Biochem/physiol Actions: | PKCη (protein kinase C η) mainly participates in terminal differentiation of keratinocytes. It is responsible for arresting the cell cycle at G1 phase. It is also involved in phosphorylation of p21 and suppression of cdk2 (cyclin-dependent kinase 2) kinase activity by associating with cyclin E/cdk2/p21 complex, thereby regulating cell cycle. PKCη is upregulated in breast cancer and is associated with cell growth. |
| General description: | PKCη (protein kinase C η) belongs to the protein kiinase C family. It is mainly expressed in the squamous cell epithelia. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 73-99 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |