Poloxamer 188
SIGMA/K4894 - solid
Synonym: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Lutrol F68
CAS Number: 9003-11-6
MDL Number: MFCD00082049
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K4894-500G
| agency | meets USP testing specifications |
| USP/NF | |
| application(s) | sample preservation |
| form | solid |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3 |
| InChI key | RVGRUAULSDPKGF-UHFFFAOYSA |
| mol wt | 8.400 g/mol |
| pH | 5.0-7.5(2.5% solution) |
| Quality Level | 300  |
| SMILES string | O2C(C2)C.O1CC1 |
| Application: | Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads. |
| Application: | Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage. |
| Biochem/physiol Actions: | Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2. |
| General description: | Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends. |
| Packaging: | 500 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12161902 |